{"id":3768,"date":"2025-11-16T23:02:21","date_gmt":"2025-11-16T22:02:21","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=3768"},"modified":"2025-11-16T23:02:21","modified_gmt":"2025-11-16T22:02:21","slug":"tratamientos-de-precision-para-el-glioblastoma-resultados-de-un-ensayo-clinico","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2025\/11\/16\/tratamientos-de-precision-para-el-glioblastoma-resultados-de-un-ensayo-clinico\/","title":{"rendered":"Tratamientos de precisi\u00f3n para el glioblastoma: resultados de un ensayo cl\u00ednico"},"content":{"rendered":"<p class=\"has-text-align-center\">La revista <a href=\"https:\/\/www.nature.com\/\">Nature Medicine<\/a> ha publicado los resultados de un ensayo cl\u00ednico en el que se prueban terapias dirigidas frente a receptores moleculares espec\u00edficos combinadas con Radioterapia para tratar glioblastomas que no presentan metilaci\u00f3n del promotor MGMT.<\/p>\n\n\n\n<p class=\"has-text-align-center\">Se probaron un total de 5 mol\u00e9culas: alectinib, idasanutlin, palbociclib, vismodegib y temsirolimus, de las cu\u00e1les la \u00faltima, que act\u00faa sobre la v\u00eda mTOR, \u00a0mostr\u00f3 resultados prometedores debido a que fue capaz de prolongar de forma significativa tanto la proporci\u00f3n de pacientes libres de progresi\u00f3n de enfermedad a los 6 meses (39,1% frente a 18,5%) , as\u00ed como la supervivencia (15,1 frente a 12,4 meses).<\/p>\n\n\n\n<p class=\"has-text-align-center\">Estos hallazgos suponen cierta esperanza de cara a plantear futuros trabajos que profundicen en el potencial de la aplicaci\u00f3n de este f\u00e1rmaco para esta compleja enfermedad.<\/p>\n\n\n\n<p><strong>Fuente:<\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12532562\/\">Wick W, Lanz LM, Wick A, Harting I, Dettmer S, Suwala AK, Ketter R, Tabatabai G, Seliger C, Glas M, Burger MC, Timmer M, Ringel FA, Mildenberger I, Schulz-Schaeffer WJ, Winkler F, K\u00f6nig L, Herold-Mende C, Eisenmenger A, Pfister SM, Renovanz M, Bendszus M, Sahm F, Platten M, Kessler T. Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1\/2a N<sup>2<\/sup>M<sup>2<\/sup>\u00a0umbrella trial. Nat Med. 2025 Oct;31(10):3534-3541.<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>La revista Nature Medicine ha publicado los resultados de un ensayo cl\u00ednico en el que se prueban terapias dirigidas frente a receptores moleculares espec\u00edficos combinadas con Radioterapia para tratar glioblastomas que no presentan metilaci\u00f3n del promotor MGMT. Se probaron un total de 5 mol\u00e9culas: alectinib, idasanutlin, palbociclib, vismodegib y temsirolimus, de las cu\u00e1les la \u00faltima,&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1771],"tags":[],"class_list":["post-3768","post","type-post","status-publish","format-standard","hentry","category-sin-categoria"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-YM","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=3768"}],"version-history":[{"count":2,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3768\/revisions"}],"predecessor-version":[{"id":3770,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3768\/revisions\/3770"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=3768"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=3768"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=3768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}