{"id":3293,"date":"2025-02-16T18:58:56","date_gmt":"2025-02-16T17:58:56","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=3293"},"modified":"2025-02-16T18:58:56","modified_gmt":"2025-02-16T17:58:56","slug":"firma-metabolomica-estilos-de-vida-reserva-cerebral-y-riesgo-de-demencia","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2025\/02\/16\/firma-metabolomica-estilos-de-vida-reserva-cerebral-y-riesgo-de-demencia\/","title":{"rendered":"Firma metabol\u00f3mica, estilos de vida, reserva cerebral y riesgo de demencia"},"content":{"rendered":"<p class=\"has-text-align-center wp-block-paragraph\">La revista <a href=\"https:\/\/academic.oup.com\/brain\">Brain<\/a> ha publicado recientemente un trabajo que trata de establecer relaciones entre marcadores metabolicos y riesgo de demencia.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Pese a que se conoce la relaci\u00f3n existe entre factores de riesgo cardiovasculares y desarrollo de este tipo de &nbsp;enfermedades, el presente trabajo trata de profundizar en el papel marcadores metab\u00f3licos relacionados con estilos de vida asi como marcadores morfologicos de la estructura cerebral. Se trat\u00f3 de definir as\u00ed una \u201cfirma metabol\u00f3mica\u201d que caracterice determinados estilos de vida y venga definida por los valores obtenidos en m\u00faltiples biomarcadores.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Para ello se llev\u00f3 a cabo un seguimiento medio de m\u00e1s de 12 a\u00f1os en m\u00e1s de 130.000 individuos de los cuales 1783 desarrollaron un cuadro de demencia, de tipo Alzheimer en 725 y tipo vascular en 418 casos.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Se identific\u00f3 un aumento de riesgo para el desarrollo de demencia en aquellos individuos con desviaciones en par\u00e1metros metabol\u00f3micos relacionados con los factores de riesgo cardiovasculares. Fueron identificados un total de 83 biomarcadores metab\u00f3licos de los cuales pudo inferirse una firma metabol\u00f3mica individual con una determinada correlaci\u00f3n con el riesgo para desarrollar demencia. Esto present\u00f3 asociaci\u00f3n adem\u00e1s con cambios estructurales cerebrales a nivel de regiones clave como el hipocampo la circunvoluci\u00f3n temporal media.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fuente: <\/strong>\u00a0<a href=\"https:\/\/academic.oup.com\/brain\/article\/148\/1\/143\/7776058\">Tian F, Wang Y, Qian ZM, Ran S, Zhang Z, Wang C, McMillin SE, Chavan NR, Lin H. Plasma metabolomic signature of healthy lifestyle, structural brain reserve and risk of dementia. Brain. 2025 Jan 7;148(1):143-153. <\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>La revista Brain ha publicado recientemente un trabajo que trata de establecer relaciones entre marcadores metabolicos y riesgo de demencia. Pese a que se conoce la relaci\u00f3n existe entre factores de riesgo cardiovasculares y desarrollo de este tipo de &nbsp;enfermedades, el presente trabajo trata de profundizar en el papel marcadores metab\u00f3licos relacionados con estilos de&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1771],"tags":[],"class_list":["post-3293","post","type-post","status-publish","format-standard","hentry","category-sin-categoria"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-R7","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=3293"}],"version-history":[{"count":2,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3293\/revisions"}],"predecessor-version":[{"id":3295,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/3293\/revisions\/3295"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=3293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=3293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=3293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}