{"id":2589,"date":"2024-05-19T22:53:01","date_gmt":"2024-05-19T20:53:01","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=2589"},"modified":"2024-05-19T22:53:01","modified_gmt":"2024-05-19T20:53:01","slug":"andexanet-nuevo-antidoto-para-frenar-la-hemorragia-cerebral-en-personas-anticoaguladas","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2024\/05\/19\/andexanet-nuevo-antidoto-para-frenar-la-hemorragia-cerebral-en-personas-anticoaguladas\/","title":{"rendered":"Andexanet: Nuevo ant\u00eddoto para frenar la hemorragia cerebral en personas anticoaguladas"},"content":{"rendered":"<p class=\"has-text-align-center wp-block-paragraph\">El New England Journal of Medicine acaba de publicar un ensayo cl\u00ednico que analiza el papel de Andexanet un nuevo ant\u00eddoto espec\u00edfico para frenar el efecto de los f\u00e1rmacos anticoagulantes anti Xa.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Los antiXa (Rivaroxab\u00e1n, Apixab\u00e1n, Edoxab\u00e1n&#8230;), medicamentos empleados com\u00fanmente para prevenir el desarrollo de trombos en personas predispuestas, presentan como principal efecto adverso el riesgo de hemorragias que pueden resultar de dif\u00edcil control hasta el punto de comprometer la vida de quienes las presentan.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">El trabajo cont\u00f3 con m\u00e1s de 500 pacientes anticoagulados con antiXa que hab\u00edan sufrido hemorragias cerebrales. Se llev\u00f3 a cabo una aleatorizaci\u00f3n en proporci\u00f3n 1:1 con un grupo de tratamiento que recibi\u00f3 Andexanet y otro grupo en el que se llev\u00f3 a cabo el manejo usual con administraci\u00f3n de complejo protromb\u00ednico.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Los autores apreciaron que la hemorragia se estabiliz\u00f3 en el 67% de los pacientes que recibieron Andexanet mientras que esto sucedi\u00f3 en el 53% de los pacientes con manejo est\u00e1ndar resultando dicha diferencia estad\u00edsitcamente significativa. En cambio, el principal efecto adeverso de estos f\u00e1rmacos, la trombosis, apareci\u00f3 de forma &nbsp;m\u00e1s frecuente como efecto adverso de Andaxanet frente al manejo est\u00e1ndar (10,3% frente a 5,6%).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span style=\"text-decoration: underline\">Fuente:<\/span> <\/strong><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2313040\">Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Cz\u0142onkowska A, Lindgren AG, Molina CA, Bereczki D, Toni D, Seiffge DJ, Tanne D, Sandset EC, Tsivgoulis G, Christensen H, Beyer-Westendorf J, Coutinho JM, Crowther M, Verhamme P, Amarenco P, Roine RO, Mikulik R, Lemmens R, Veltkamp R, Middeldorp S, Robinson TG, Milling TJ Jr, Tedim-Cruz V, Lang W, Himmelmann A, Ladenvall P, Knutsson M, Ekholm E, Law A, Taylor A, Karyakina T, Xu L, Tsiplova K, Poli S, Kallm\u00fcnzer B, Gumbinger C, Shoamanesh A; ANNEXA-I Investigators. Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. N Engl J Med. 2024 May 16;390(19):1745-1755.\u00a0<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>El New England Journal of Medicine acaba de publicar un ensayo cl\u00ednico que analiza el papel de Andexanet un nuevo ant\u00eddoto espec\u00edfico para frenar el efecto de los f\u00e1rmacos anticoagulantes anti Xa. Los antiXa (Rivaroxab\u00e1n, Apixab\u00e1n, Edoxab\u00e1n&#8230;), medicamentos empleados com\u00fanmente para prevenir el desarrollo de trombos en personas predispuestas, presentan como principal efecto adverso el&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1771],"tags":[],"class_list":["post-2589","post","type-post","status-publish","format-standard","hentry","category-sin-categoria"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-FL","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/2589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=2589"}],"version-history":[{"count":2,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/2589\/revisions"}],"predecessor-version":[{"id":2591,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/2589\/revisions\/2591"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=2589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=2589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=2589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}