{"id":1735,"date":"2022-10-04T13:43:08","date_gmt":"2022-10-04T11:43:08","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=1735"},"modified":"2022-10-04T13:43:08","modified_gmt":"2022-10-04T11:43:08","slug":"modelos-predictivos-de-supervivencia-en-glioblastoma-idh-salvaje-desarrollo-y-validacion-externa","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2022\/10\/04\/modelos-predictivos-de-supervivencia-en-glioblastoma-idh-salvaje-desarrollo-y-validacion-externa\/","title":{"rendered":"Modelos predictivos de supervivencia en Glioblastoma IDH salvaje: Desarrollo y validaci\u00f3n externa"},"content":{"rendered":"<p class=\"has-text-align-center wp-block-paragraph\">El desarrollo de escalas predictivas capaces de vaticinar la evoluci\u00f3n de las enfermedades representa uno de los campos actualmente en crecimiento derivado de las aplicaciones del an\u00e1lisis de datos a gran escala y al empleo de la Inteligencia Artificial.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">En el glioma de alto grado, la incorporaci\u00f3n de informaci\u00f3n relacionada con la expresi\u00f3n gen\u00e9tica del tumor ha permitido en los \u00faltimos a\u00f1os un mejor conocimiento de la enfermedad. Ello ha facilitado la generaci\u00f3n de este tipo de modelos predictivos.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">En el \u00faltimo n\u00famero de la revista <a href=\"https:\/\/www.bing.com\/search?q=journal+of+neurosurgery&amp;cvid=62de83f9d31d48b3bea4ba05db8f2046&amp;aqs=edge.1.69i57j46j0l5j69i60l2.3716j0j1&amp;pglt=299&amp;FORM=ANNTA1&amp;PC=HCTS\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Neurosurgery<\/a> autores alemanes y holandeses presentan su modelo y el proceso de validaci\u00f3n externa del mismo que tuvo lugar sobre 1036 pacientes diagnosticados entre 2012 y 2018 de los cuales el 95% hab\u00eda fallecido en el momento de llevar a cabo el estudio.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Tras llevar a cabo el ajusto este modelo predictivo incluy\u00f3 finalmente en su algoritmo las variables: edad, el sexo, la condici\u00f3n general preoperatoria seg\u00fan la escala KArnofsky, grado de resecci\u00f3n, estado mutacional de la metilaci\u00f3n MGMT y cumplimiento del tratamiento adyuvante.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Los autores concluyeron que se trata de un modelo predictivo reproducible para la mayor\u00eda de los casos, por lo que puede ser de utilidad en la toma de decisiones. Requerir\u00eda no obstante un mayor refinamiento de cara a poder explicar aquellos casos de supervivencia prolongada que no se ajustan al mismo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span style=\"text-decoration:underline;\">Fuente: <\/span><\/strong><a href=\"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/aop\/article-10.3171-2021.10.JNS211261\/article-10.3171-2021.10.JNS211261.xml\" target=\"_blank\" rel=\"noreferrer noopener\">Mijderwijk HJ, Nieboer D, Incekara F, Berger K, Steyerberg EW, van den Bent MJ, Reifenberger G, H\u00e4nggi D, Smits M, Senft C, Rapp M, Sabel M, Voss M, Forster MT, Kamp MA. Development and external validation of a clinical prediction model for survival in patients with IDH wild-type glioblastoma. J Neurosurg. 2022 Jan 14:1-10. doi: 10.3171\/2021.10.JNS211261. Epub ahead of print. PMID: 35171829.<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>El desarrollo de escalas predictivas capaces de vaticinar la evoluci\u00f3n de las enfermedades representa uno de los campos actualmente en crecimiento derivado de las aplicaciones del an\u00e1lisis de datos a gran escala y al empleo de la Inteligencia Artificial. En el glioma de alto grado, la incorporaci\u00f3n de informaci\u00f3n relacionada con la expresi\u00f3n gen\u00e9tica del&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[706700519,706700523,706700521,706700514,15936531,706700522,706700517],"tags":[],"class_list":["post-1735","post","type-post","status-publish","format-standard","hentry","category-almeria","category-bionica","category-futurismo","category-neurocirugia","category-neurooncologia","category-transhumanismo","category-zerotohero"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-rZ","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=1735"}],"version-history":[{"count":2,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1735\/revisions"}],"predecessor-version":[{"id":1737,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1735\/revisions\/1737"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=1735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=1735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=1735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}