{"id":1728,"date":"2022-09-06T08:22:52","date_gmt":"2022-09-06T06:22:52","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=1728"},"modified":"2022-09-06T08:22:52","modified_gmt":"2022-09-06T06:22:52","slug":"biopsia-liquida-en-tumores-cerebrales-pediatricos-camino-por-recorrer","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2022\/09\/06\/biopsia-liquida-en-tumores-cerebrales-pediatricos-camino-por-recorrer\/","title":{"rendered":"Biopsia l\u00edquida en tumores cerebrales pedi\u00e1tricos: Camino por recorrer"},"content":{"rendered":"<p class=\"has-text-align-center wp-block-paragraph\">La biopsia l\u00edquida consistente en la obtenci\u00f3n de material gen\u00e9tico liberado por los tumores cerebrales en la sangre o en otros fluidos corporalees, se ha postulado en los \u00faltimos a\u00f1os como posible herramienta hipot\u00e9ticamente capaz de permitir la caracterizaci\u00f3n de estos tumores sin la necesidad de realizar una biopsia cerebral. Esto favorecer\u00eda el desarrollo de terapias dirigidas para cada caso en lo que se conoce como Medicina de Precisi\u00f3n aplicada al tratamiento del c\u00e1ncer.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">La revista <a href=\"https:\/\/academic.oup.com\/neuro-oncology\" target=\"_blank\" rel=\"noreferrer noopener\">Neurooncology<\/a> ha publicado los resultados de un trabajo prospectivo en el que fueron analizados m\u00e1s de 250 casos con diferentes tumores cerebrales pedi\u00e1tricos. Se llev\u00f3 a cabo la obtenci\u00f3n de material gen\u00e9tico procedente de sangre, l\u00edquido cefalorraqu\u00eddeo y orina.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Los autores encontraron grandes dificultades para obtener material gen\u00e9tico v\u00e1lido para la detecci\u00f3n de alteraciones gen\u00e9ticas concluyentes. El an\u00e1lisis de l\u00edquido cefalorraqu\u00eddeo mostr\u00f3 mayor capacidad para proporcionar dicho material si bien tampoco alcanz\u00f3 el nivel deseable.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Adem\u00e1s de la dificultad para obtener dicho material el n\u00famero de mutaciones som\u00e1ticas presentes en el mismo y la capacidad de los procedimientos de secuenciaci\u00f3n para detectar alteraciones gen\u00e9ticas fueron igualmente limitados, existiendo no obstante mayor rentabilidad diagn\u00f3stica en el subgrupo de tumores cerebrales malignos, que en cualquier caso tampoco alcanz\u00f3 un nivel m\u00ednimo deseable.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Las conclusiones de los autores se\u00f1alan que pese a las esperanzas depositadas en la biopsia l\u00edquida de los tumores cerebrales existen a\u00fan muchos obst\u00e1culos por superar de cara a que este procedimiento posibilite la secuenciaci\u00f3n completa de los tumores cerebrales.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><span style=\"text-decoration:underline;\"><strong>Fuente<\/strong>:<\/span> <a href=\"https:\/\/academic.oup.com\/neuro-oncology\/article\/24\/8\/1352\/6497435\" target=\"_blank\" rel=\"noreferrer noopener\">M\u00e9lanie Pag\u00e8s, Denisse Rotem, Gregory Gydush, Sarah Reed, Justin Rhoades, Gavin Ha, Christopher Lo, Mark Fleharty, Madeleine Duran, Robert Jones, Sarah Becker, Michaela Haller, Claire E Sinai, Liliana Goumnerova, Todd R Golub, J Christopher Love, Keith L Ligon, Karen D Wright, Viktor A Adalsteinsson, Rameen Beroukhim, Pratiti Bandopadhayay, Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine, <em>Neuro-Oncology<\/em>, Volume 24, Issue 8, August 2022, Pages 1352\u20131363.<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>La biopsia l\u00edquida consistente en la obtenci\u00f3n de material gen\u00e9tico liberado por los tumores cerebrales en la sangre o en otros fluidos corporalees, se ha postulado en los \u00faltimos a\u00f1os como posible herramienta hipot\u00e9ticamente capaz de permitir la caracterizaci\u00f3n de estos tumores sin la necesidad de realizar una biopsia cerebral. Esto favorecer\u00eda el desarrollo de&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[706700519,706700523,706700518,64833440,706700521,706700514,15936531,706700522,706700517],"tags":[],"class_list":["post-1728","post","type-post","status-publish","format-standard","hentry","category-almeria","category-bionica","category-cirugia-de-columna","category-estimulacion-cerebral-profunda","category-futurismo","category-neurocirugia","category-neurooncologia","category-transhumanismo","category-zerotohero"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-rS","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=1728"}],"version-history":[{"count":3,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1728\/revisions"}],"predecessor-version":[{"id":1731,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1728\/revisions\/1731"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=1728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=1728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=1728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}