{"id":1200,"date":"2021-11-16T22:22:27","date_gmt":"2021-11-16T21:22:27","guid":{"rendered":"https:\/\/neurocirugialmeria.com\/?p=1200"},"modified":"2021-11-16T22:22:27","modified_gmt":"2021-11-16T21:22:27","slug":"papel-de-la-alteplasa-previo-a-la-trombectomia-mecanica-en-el-tratamiento-del-ictus-isquemico","status":"publish","type":"post","link":"https:\/\/neurocirugialmeria.com\/en\/2021\/11\/16\/papel-de-la-alteplasa-previo-a-la-trombectomia-mecanica-en-el-tratamiento-del-ictus-isquemico\/","title":{"rendered":"Papel de la Alteplasa previo a la trombectom\u00eda mec\u00e1nica en el tratamiento del ictus isqu\u00e9mico"},"content":{"rendered":"<p class=\"has-text-align-center wp-block-paragraph\">El<a href=\"https:\/\/www.nejm.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">&nbsp;New England Journal of Medicine<\/a>&nbsp;acaba de publicar un ensayo multic\u00e9ntrico en el que se analiza el papel de la Alteplasa, f\u00e1rmaco fibrinol\u00edtico, en el tratamiento del ictus isqu\u00e9mico en aquellos casos en que se lleva a cabo la trombectom\u00eda mec\u00e1nica.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Si bien se acepta el empleo de este f\u00e1rmaco (salvo contrainidcaci\u00f3n) previo a realizar la trombectom\u00eda en el tratamiento del ictus isqu\u00e9mico, exist\u00edan ya trabajos llevados a cabo sobre poblaci\u00f3n asi\u00e1tica que cuestionaban la existencia de un beneficio adicional debido a la administraci\u00f3n de este compuesto.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">En total fueron incluidos 539 pacientes aleatorizados en dos grupos en una proporci\u00f3n 1:1; de manera que en uno de los grupos se llev\u00f3 a cabo exclusivamente la trombectom\u00eda mec\u00e1nica mientras que en\u00a0 el otro \u00e9sta fue precidida de la administraci\u00f3n de Alteplasa.  Para valorar los resultados se determin\u00f3 la puntuaci\u00f3n de los pacientes en la escala de Rankin modificada a los 3 meses, as\u00ed como el desarrollo de hemorragia cerebral o muerte.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Los autores apreciaron que no exist\u00eda ventaja alguna en la recuperaci\u00f3n neurol\u00f3gica\u00a0ni desventaja (desarrollo de hemorragia u otras complicaciones)\u00a0en el resultado final al administrar Alteplasa en pacientes en los que se llevaba a cabo la revascularizaci\u00f3n del ictus isqu\u00e9mico mediante trombectom\u00eda mec\u00e1nica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><span style=\"text-decoration:underline;\">Fuente: <\/span><\/strong><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2107727\" target=\"_blank\" rel=\"noreferrer noopener\">LeCouffe NE, Kappelhof M, Treurniet KM, Rinkel LA, Bruggeman AE, Berkhemer OA, Wolff L, van Voorst H, Tolhuisen ML, Dippel DWJ, van der Lugt A, van Es ACGM, Boiten J, Lycklama \u00c0 Nijeholt GJ, Keizer K, Gons RAR, Yo LSF, van Oostenbrugge RJ, van Zwam WH, Roozenbeek B, van der Worp HB, Lo RTH, van den Wijngaard IR, de Ridder IR, Costalat V, Arquizan C, Lemmens R, Demeestere J, Hofmeijer J, Martens JM, Schonewille WJ, Vos JA, Uyttenboogaart M, Bokkers RPH, van Tuijl JH, Kortman H, Schreuder FHBM, Boogaarts HD, de Laat KF, van Dijk LC, den Hertog HM, van Hasselt BAAM, Brouwers PJAM, Bulut T, Remmers MJM, van Norden A, Imani F, Rozeman AD, Elgersma OEH, Desfontaines P, Brisbois D, Samson Y, Claren\u00e7on F, Krietemeijer GM, Postma AA, van Doormaal PJ, van den Berg R, van der Hoorn A, Beenen LFM, Nieboer D, Lingsma HF, Emmer BJ, Coutinho JM, Majoie CBLM, Roos YBWEM; MR CLEAN\u2013NO IV Investigators. A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke. N Engl J Med. 2021 Nov 11;385(20):1833-1844.<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>El&nbsp;New England Journal of Medicine&nbsp;acaba de publicar un ensayo multic\u00e9ntrico en el que se analiza el papel de la Alteplasa, f\u00e1rmaco fibrinol\u00edtico, en el tratamiento del ictus isqu\u00e9mico en aquellos casos en que se lleva a cabo la trombectom\u00eda mec\u00e1nica. Si bien se acepta el empleo de este f\u00e1rmaco (salvo contrainidcaci\u00f3n) previo a realizar la&#8230;<\/p>","protected":false},"author":183523340,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"jetpack_seo_schema_type":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[706700519,706700523,706700521,706700514,86215848,706700522,706700517],"tags":[],"class_list":["post-1200","post","type-post","status-publish","format-standard","hentry","category-almeria","category-bionica","category-futurismo","category-neurocirugia","category-neuromodulacion","category-transhumanismo","category-zerotohero"],"jetpack_publicize_connections":[],"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbS7CP-jm","jetpack-related-posts":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/users\/183523340"}],"replies":[{"embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/comments?post=1200"}],"version-history":[{"count":2,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1200\/revisions"}],"predecessor-version":[{"id":1202,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/posts\/1200\/revisions\/1202"}],"wp:attachment":[{"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/media?parent=1200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/categories?post=1200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurocirugialmeria.com\/en\/wp-json\/wp\/v2\/tags?post=1200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}